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KMID : 0603519990040020086
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Journal of Korean Association of Cancer Prevention
1999 Volume.4 No. 2 p.86 ~ p.92
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Scavenging Activity of Peroxynitrite and Total Free Radicals of Korean Traditional Teas
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Kye In-Sook
Jeon Young-Soo
Lee Suk-Hee
No Jae-Kyung
Shim Kyung-Hee
Kim You-Jung
Baek Bong-Sook
Kim Jong
Chung Hae-Young
Kim Han-Do
Yu Byung-Pal
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Abstract
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The "Oxygen Paradox" is that higher eukaryotic aerobic organisms cannot exist without oxygen, yet oxygen is inherently dangerous to their existence. Moreover, reactive oxygen species (O2-, H2O2, ·OH) and peroxynitrite (ONOO-) are proposed as agents attacking fatty acids in cells, tissues, or organism, giving rise to an oxidative damage of biologically important molecules. Especially, ONOO- formed from superoxide (O2-) and nitric oxide (NO·) acts as a strong cytotoxicant giving carcinogenisis, cell death and low density lipoprotein oxidation. In the present study, 21 kinds of teas including cereal teas (job’s tears tea, roasted barley tea, roasted indian corn tea, scorched rice tea), fruit teas (boxthorn tea, chinese quince tea, citron tea, dried persimmon tea, jujube tea, ky lmy ngia tea, sansuyoo tea), leaf teas (black tea, duch’ung tea, green tea, oolong tea, persimmon leaf tea) and root teas (arrowroot tea, chicory tea, ginger tea, ginseng tea, solomon’s seal tea) were screened for the scavenging activities against peroxynitrite formation by SIN-1 and peroxynitrite itself. Green tea showed the strongest peroxynitrite scavenging activity. Moreover, 21 kinds of teas including cereal teas, fruit teas, leaf teas and root teas were screened for the scavenging effects against total free radical formation by using DCFDA assay. Among the several teas, green tea showed the strongest scavenging activity respectively. These results suggest that green tea might show cytoprotective action through antioxidant and peroxynitrite scavenging activity.
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KEYWORD
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Korean traditional teas, Peroxynitrite, Total free radicals
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